Department of Molecular Evolution, Biomedical Center, Uppsala University, Box 596, SE-751 24, Uppsala, Sweden.
Trends Microbiol. 2011 Dec;19(12):580-7. doi: 10.1016/j.tim.2011.09.002. Epub 2011 Oct 20.
Although most hypotheses to explain the emergence of the eukaryotic lineage are conflicting, some consensus exists concerning the requirement of a genomic fusion between archaeal and bacterial components. Recent phylogenomic studies have provided support for eocyte-like scenarios in which the alleged 'archaeal parent' of the eukaryotic cell emerged from the Crenarchaeota/Thaumarchaeota. Here, we provide evidence for a scenario in which this archaeal parent emerged from within the 'TACK' superphylum that comprises the Thaumarchaeota, Crenarchaeota and Korarchaeota, as well as the recently proposed phylum 'Aigarchaeota'. In support of this view, functional and comparative genomics studies have unearthed an increasing number of features that are uniquely shared by the TACK superphylum and eukaryotes, including proteins involved in cytokinesis, membrane remodeling, cell shape determination and protein recycling.
尽管大多数解释真核生物谱系出现的假说相互矛盾，但对于古菌和细菌成分之间需要基因组融合这一点，存在一些共识。最近的系统基因组学研究为所谓的真核细胞“古菌祖先”源自泉古菌/广古菌的“卵母细胞样情景”提供了支持。在这里，我们提供的证据表明，这种古菌祖先来自于包括泉古菌、广古菌和奇古菌以及最近提出的门“Aigarchaeota”的“TACK”超门。支持这一观点的是，功能和比较基因组学研究揭示了越来越多的 TACK 超门和真核生物所特有的特征，包括参与胞质分裂、膜重塑、细胞形状决定和蛋白质回收的蛋白质。
