真核生物的古菌遗传：系统基因组学视角
The archaeal legacy of eukaryotes: a phylogenomic perspective.
作者信息
Guy Lionel, Saw Jimmy H, Ettema Thijs J G
机构信息
Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, SE-75123, Uppsala, Sweden.
出版信息
Cold Spring Harb Perspect Biol. 2014 Jul 3;6(10):a016022. doi: 10.1101/cshperspect.a016022.
The origin of the eukaryotic cell can be regarded as one of the hallmarks in the history of life on our planet. The apparent genomic chimerism in eukaryotic genomes is currently best explained by invoking a cellular fusion at the root of the eukaryotes that involves one archaeal and one or more bacterial components. Here, we use a phylogenomics approach to reevaluate the evolutionary affiliation between Archaea and eukaryotes, and provide further support for scenarios in which the nuclear lineage in eukaryotes emerged from within the archaeal radiation, displaying a strong phylogenetic affiliation with, or even within, the archaeal TACK superphylum. Further taxonomic sampling of archaeal genomes in this superphylum will certainly provide a better resolution in the events that have been instrumental for the emergence of the eukaryotic lineage.
真核细胞的起源可被视为我们星球生命史上的标志性事件之一。目前，真核生物基因组中明显的基因组嵌合现象，最好的解释是在真核生物起源时发生了一次细胞融合，涉及一个古菌成分和一个或多个细菌成分。在这里，我们采用系统发育基因组学方法重新评估古菌与真核生物之间的进化关系，并为真核生物的核谱系起源于古菌辐射范围内的观点提供进一步支持，显示出与古菌TACK超群有很强的系统发育关系，甚至是在该超群内部。对这个超群中古菌基因组进行进一步的分类采样，肯定会为有助于真核生物谱系出现的事件提供更好的解析度。
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