Chêne G, Raoelfils I, Cayre A, Dauplat J, Bignon Y-J, Jaffeux P, Aublet-Cuvelier B, Penault-Llorca F
Département d'anatomopathologie, centre Jean-Perrin, boulevard Montalembert, 63000 Clermont-Ferrand, France.
Gynecol Obstet Fertil. 2012 Jan;40(1):14-8. doi: 10.1016/j.gyobfe.2011.07.043. Epub 2011 Oct 21.
The objective of this study was to describe morphologic and immunohistochemical features of precursor tubal lesions in prophylactically removed Fallopian tubes.
Hundred and forty-seven bilateral salpingectomies (genetic predisposition or group A: n=57; and control group or group B: n=90) were reviewed by two pathologists blinded to clinical data. Seven epithelial cytological and architectural features were studied to compare the degree of tubal epithelial abnormalities between the two groups. Immunohistochemical expression patterns of Ki67 and p53 were also evaluated.
Serous tubal intraepithelial lesions (STIL) have been identified in group A with stronger expression for Ki67 and p53 (especially in BRCA 1 group) than in group B.
The current results show the importance of salpingo-oophrectomy in BRCA mutation carriers and the complete histopathological sampling of the Fallopian tubes.
本研究的目的是描述预防性切除的输卵管中输卵管前驱病变的形态学和免疫组化特征。
两名对临床数据不知情的病理学家对147例双侧输卵管切除术（遗传易感性或A组：n = 57；对照组或B组：n = 90）进行了回顾。研究了七种上皮细胞学和结构特征，以比较两组之间输卵管上皮异常的程度。还评估了Ki67和p53的免疫组化表达模式。
在A组中发现了浆液性输卵管上皮内病变（STIL），其Ki67和p53的表达（尤其是在BRCA 1组中）比B组更强。
目前的结果显示了输卵管卵巢切除术在BRCA突变携带者中的重要性以及输卵管完整的组织病理学取样的重要性。
