Department of Neurology, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia.
Epilepsy Res. 2012 Feb;98(2-3):182-6. doi: 10.1016/j.eplepsyres.2011.09.011. Epub 2011 Oct 21.
Previous studies have evaluated the inter-session variability of motor thresholds (MT), short intracortical inhibition and intracortical facilitation using paired pulse transcranial magnetic stimulation (TMS) in normal individuals. Here we evaluate the reproducibility of a range of measures of cortical excitability in patients with epilepsy.
Twenty-four drug naïve patients with newly diagnosed epilepsy (13 idiopathic generalised epilepsy [IGE], 11 focal epilepsy) and seventeen non-epilepsy controls were studied. Motor threshold (MT) at rest and recovery curves constructed using paired pulse stimulation at short (2-15 ms) and long (50-400 ms) interstimulus intervals (ISIs) were analysed on two separate occasions, 4-20 weeks apart. The Lin's concordance correlation coefficient test was used to measure agreement between the two sessions.
Significant levels of agreement between the two sessions were observed at MT and all the ISIs measured. This was highest in non-epilepsy controls.
Cortical excitability measures are repeatable over time in both patients with epilepsy and healthy controls. Increased motor cortex excitability is a stable feature in epilepsy without significant inter-session variability.
先前的研究已经使用双脉冲经颅磁刺激（TMS）评估了正常个体的运动阈值（MT）、短程皮质内抑制和皮质内易化的会话间变异性。在这里，我们评估了一系列癫痫患者皮质兴奋性测量值的重现性。
研究了 24 名新诊断为癫痫的药物-naive 患者（13 名特发性全面性癫痫[IGE]，11 名局灶性癫痫）和 17 名非癫痫对照组。使用双脉冲刺激在短（2-15 ms）和长（50-400 ms）刺激间隔（ISIs）下构建的静息和恢复曲线的运动阈值（MT）进行了分析，两次之间相隔 4-20 周。使用 Lin 的一致性相关系数检验来测量两次会话之间的一致性。
在 MT 和测量的所有 ISIs 中，两个会话之间均观察到显著的一致性水平。在非癫痫对照组中，这种一致性最高。
在癫痫患者和健康对照组中，皮质兴奋性测量值在时间上具有可重复性。运动皮质兴奋性增加是癫痫的一个稳定特征，没有明显的会话间变异性。
