体外时间杀菌分析研究奥他万古霉素对耐甲氧西林金黄色葡萄球菌临床分离株的杀菌作用，这些分离株对达托霉素的敏感性降低。
In vitro time-kill analysis of oritavancin against clinical isolates of methicillin-resistant Staphylococcus aureus with reduced susceptibility to daptomycin.
机构信息
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
出版信息
Diagn Microbiol Infect Dis. 2011 Dec;71(4):470-3. doi: 10.1016/j.diagmicrobio.2011.09.002. Epub 2011 Oct 21.
Oritavancin exhibited lower MIC(50) values (0.03 and 0.5 mg/L) than comparators against methicillin-resistant Staphylococcus aureus (MRSA, n = 50) and vancomycin-intermediate SA strains (n = 60). At subtherapeutic concentrations, oritavancin demonstrated rapid (within 9 h) and concentration-dependent bactericidal activity against daptomycin nonsusceptible (DNS) MRSA. Further investigations are warranted to determine the therapeutic potential of oritavancin against DNS MRSA.
奥他万古霉素对耐甲氧西林金黄色葡萄球菌（MRSA，n = 50）和万古霉素中介金黄色葡萄球菌（n = 60）的 MIC50 值（0.03 和 0.5 mg/L）均低于对照药物。在低于治疗浓度时，奥他万古霉素对达托霉素不敏感的耐甲氧西林金黄色葡萄球菌（DNS-MRSA）具有快速（9 小时内）和浓度依赖性杀菌活性。需要进一步研究来确定奥他万古霉素治疗 DNS-MRSA 的潜力。
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