Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Rd, Tainan 704, Taiwan.
Sci Total Environ. 2011 Dec 1;410-411:41-6. doi: 10.1016/j.scitotenv.2011.09.028. Epub 2011 Oct 20.
Environmental temperature is known to correlate with schizophrenia, but little is known about the association with changes in temperature. This 12-year study aimed to evaluate the relationship between the mean daily range of ambient temperature and schizophrenia admissions in a national cohort of psychiatric inpatients in Taiwan. Meteorological data provided by the Central Weather Bureau of Taiwan were interpolated to create representative estimates. Psychiatric inpatient admissions in all hospitals with medical services enrolled in the current health care insurance system were retrieved from the 1996-2007 Psychiatric Inpatient Medical Claim dataset of the National Health Insurance Research Database. Generalized linear models with Poisson distributions were used to analyze the impact of mean diurnal change of temperature on schizophrenia admissions, controlling for internal correlations and demographic covariates. The daily temperature range varied between 1.7°C and 12.1°C (1st to 99th percentile). The relative risk of schizophrenia admission was significantly increased at a temperature range of 3.2°C (10th percentile), and the maximum was at 12.1°C (99th percentile); however, no such association was found with schizoaffective disorder. When restricted to the capital and largest city, the effects of temperature range were prominent and may correlate with temperature itself. The joint effect of temperature and temperature range was associated with elevated risk, particularly at cooler temperatures. A positive correlation was found between increasing temperature range and schizophrenia admissions. The increase in morbidity at high percentiles suggests that the increasing dynamics of temperature range are a valid reflection of risk, highlighting the need for precautionary action.
环境温度与精神分裂症相关，但对于温度变化与精神分裂症的关联知之甚少。本 12 年研究旨在评估台湾全国性精神科住院患者队列中环境温度日平均极差与精神分裂症入院率之间的关系。通过台湾中央气象局提供的气象数据进行内插，以得出有代表性的估算值。从 1996 年至 2007 年的全民健康保险研究数据库的精神病住院医疗索赔数据集，检索到参加当前医疗保险系统的所有提供医疗服务的医院的精神病住院患者入院情况。使用具有泊松分布的广义线性模型来分析平均日间温度变化对精神分裂症入院率的影响，同时控制内部相关性和人口统计学协变量。每日温度范围在 1.7°C 至 12.1°C 之间（第 1 个至第 99 个百分位数）。在温度范围为 3.2°C（第 10 个百分位数）时，精神分裂症入院的相对风险显著增加，最高值为 12.1°C（第 99 个百分位数）；然而，与分裂情感障碍并无关联。当仅限于首都和最大城市时，温度范围的影响较为显著，且可能与温度本身相关。温度和温度范围的联合作用与风险升高相关，尤其是在较冷的温度下。发现温度范围的增加与精神分裂症入院率呈正相关。在较高百分位数处发病率的增加表明，温度范围的动态增加是风险的有效反映，这凸显了采取预防措施的必要性。
