还原糖热降解产生的一种酮醛的遗传毒性效应。

Genotoxic effect of a keto-aldehyde produced by thermal degradation of reducing sugars.

作者信息

Valsa J O, Felzenszwalb I, de Araujo A C, Alcantara-Gomes R

机构信息

Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Brazil.

出版信息

Mutat Res. 1990 Sep;232(1):31-5. doi: 10.1016/0027-5107(90)90106-e.

DOI:10.1016/0027-5107(90)90106-e

PMID:2201912

Abstract

Reductone (HOCH2-CO-CHO), a keto-aldehyde formed, in alkaline pH, by thermal degradation of reducing sugars, blocks cellular respiration and macromolecular biosynthesis, inactivates far-UV (254 nm)-irradiated wild-type E. coli cells, and causes DNA strand breaks. So it may be supposed to be an inducer of SOS functions. Indeed, when Salmonella tester strains TA98, TA100 and TA102 were treated with reductone solutions, without metabolization, a mutagenic effect was detected for all of them. Besides, reductone induced lysogenic E. coli cells and cell filamentation, as measured by the Inductest and the SOS Chromotest. So reductone must be considered a genotoxic drug.

摘要

还原酮（HOCH2 - CO - CHO）是一种在碱性pH条件下由还原糖热降解形成的酮醛，它会阻断细胞呼吸和大分子生物合成，使远紫外线（254纳米）照射的野生型大肠杆菌细胞失活，并导致DNA链断裂。因此，可以认为它是SOS功能的诱导剂。事实上，当用还原酮溶液处理沙门氏菌测试菌株TA98、TA100和TA102而不进行代谢时，检测到它们都有诱变作用。此外，通过诱导试验和SOS显色试验测定，还原酮可诱导溶原性大肠杆菌细胞并导致细胞丝状化。所以，必须将还原酮视为一种具有基因毒性的药物。