萝芙木生物碱的遗传毒性、致突变性和重组效应。

Genotoxic, mutagenic and recombinogenic effects of rauwolfia alkaloids.

作者信息

von Poser G, Andrade H H, da Silva K V, Henriques A T, Henriques J A

机构信息

Curso de Pós-Graduação em Farmácia, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil.

出版信息

Mutat Res. 1990 Sep;232(1):37-43. doi: 10.1016/0027-5107(90)90107-f.

DOI:10.1016/0027-5107(90)90107-f

PMID:2201913

Abstract

In the last decade, the possible correlation between the use of reserpine and rauwolfia drugs as antihypertensive agents and breast cancer incidence has been investigated. For the purpose of evaluating the mutagenic and genotoxic effects of these drugs, reserpine and ajmalicine were studied using the SOS Chromotest and the induction of gene conversion, crossing-over and reverse mutation in the yeast diploid strain XS2316. The results indicated a lack of genotoxic, mutagenic and recombinogenic effects.

摘要

在过去十年中，已经对使用利血平和萝芙木类药物作为抗高血压药物与乳腺癌发病率之间可能存在的相关性进行了研究。为了评估这些药物的诱变和遗传毒性作用，使用SOS色变试验以及在酵母二倍体菌株XS2316中诱导基因转换、交叉和反向突变的方法，对利血平和阿吗灵进行了研究。结果表明不存在遗传毒性、诱变性和重组性作用。