Rozec B, Cinotti R, Blanloeil Y
Service d'anesthésie et de réanimation chirurgicale, hôpital G.-et-R.-Laënnec, CHU de Nantes, boulevard Jacques-Monod, 44093 Nantes cedex 1, France.
Ann Fr Anesth Reanim. 2011 Nov;30(11):828-40. doi: 10.1016/j.annfar.2011.07.012. Epub 2011 Oct 20.
Depression is the most common psychiatric disease, which is treated by the use of antidepressive agents possessing various mechanisms of action. Thus, the use in preoperative period of antidepressive agents is frequent (7% of patients scheduled for surgery). The objective of this review was to update the knowledge on the drug interactions between antidepressive agents and drugs used in perioperative period.
(i) Medline and Ovid databases using combination of antidepressive agent and perioperative period as keywords; (ii) national and European epidemiologic database; (iii) expert recommendation and official French health agency; (iv) reference book chapters.
The clinical practice showed a limited risk of adverse event related to antidepressant agents interaction with perioperative used drugs. In the two past decades, few relevant observations of adverse event related with imipramine and monoamine oxidase inhibitors use was reported. The most recent antidepressive agents had no serious adverse interaction. Nevertheless, the serotonin syndrome has to be known as far as it is more and more reported. In case of hypotension, the use of vasopressive agent has to be careful because of excessive response.
抑郁症是最常见的精神疾病，通过使用具有多种作用机制的抗抑郁药进行治疗。因此，抗抑郁药在术前使用很频繁（7%的手术患者）。本综述的目的是更新关于抗抑郁药与围手术期使用药物之间药物相互作用的知识。
（i）使用抗抑郁药和围手术期组合作为关键词检索Medline和Ovid数据库；（ii）国家和欧洲流行病学数据库；（iii）专家推荐和法国官方卫生机构；（iv）参考书籍章节。
临床实践表明，抗抑郁药与围手术期使用药物相互作用导致不良事件的风险有限。在过去二十年中，很少有关于丙咪嗪和单胺氧化酶抑制剂使用相关不良事件的相关观察报告。最新的抗抑郁药没有严重的不良相互作用。然而，由于血清素综合征报告越来越多，必须加以了解。在出现低血压的情况下，由于反应过度，使用血管升压药时必须谨慎。
