Department of Pathology, University of South Florida College of Medicine, Tampa, Florida, USA.
Surv Ophthalmol. 2012 Jan-Feb;57(1):66-76. doi: 10.1016/j.survophthal.2011.07.001. Epub 2011 Oct 22.
Samuel Johnson, the acclaimed author of the Dictionary of the English Language, survived childhood scrofula with impaired sight and hearing. The cause of his scrofula has been attributed to bovine tuberculosis, but mycobacterial infection does not satisfactorily account for the peculiar features of Johnson's eye disorder or his hearing loss. The subject of numerous biographies, Johnson may have the most scrutinized medical history of all time. Medical detectives, hampered by the vagueness of 18(th)-century diagnosis, suspect that phlyctenular eye disease related to tuberculosis was the reason for his visual impairment. Pediatric brucellosis can also explain childhood scrofula associated with visual and auditory disabilities, but it may be difficult to reconcile any single diagnosis given the uncertainties surrounding Johnson's medical and ocular histories.
塞缪尔·约翰逊,被誉为《英语语言词典》的作者,在童年时期患有淋巴结核,视力和听力受损。他的淋巴结核的病因被归因于牛型结核分枝杆菌,但分枝杆菌感染并不能很好地解释约翰逊眼部疾病或听力损失的特殊特征。作为众多传记的主题,约翰逊可能拥有有史以来最受关注的医学史。医学侦探受到 18 世纪诊断模糊性的阻碍,怀疑与结核病有关的滤泡性眼病是他视力受损的原因。儿童布鲁氏菌病也可以解释与视觉和听觉障碍相关的儿童期淋巴结核,但鉴于约翰逊的医学和眼部病史存在不确定性,很难调和任何单一诊断。