Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neurol India. 2011 Sep-Oct;59(5):700-6. doi: 10.4103/0028-3886.86544.
Multifocal motor neuropathy (MMN) is a unique disorder characterized by slowly progressive, asymmetric, distal and upper limb predominant weakness without significant sensory abnormalities. Electrophysiology is crucial to the diagnosis, revealing the hallmark partial conduction block. MMN is considered immune mediated due to the association with anti-GM1 antibodies and the response to immunomodulatory treatment. It is paramount to recognize MMN from other motor neuronopathies or peripheral neuropathies as it is treatable. Advances in pathogenesis, clinical features, electrophysiology, diagnostic studies and treatment are reviewed. References for this review were identified from literature search on Pubmed limited to dates from 1988 to 2011. Papers were selected if relevant to the review topic and published in English.
多灶性运动神经病（MMN）是一种独特的疾病，其特征为缓慢进展、不对称、远端和上肢为主的无力，无明显感觉异常。电生理学对诊断至关重要，可发现标志性的部分传导阻滞。MMN 被认为是免疫介导的，因为它与抗 GM1 抗体有关，并且对免疫调节治疗有反应。与其他运动神经元病或周围神经病相比，识别 MMN 是很重要的，因为它是可治疗的。对发病机制、临床特征、电生理学、诊断研究和治疗的进展进行了综述。本综述的参考文献是通过对 Pubmed 进行文献检索获得的，检索日期限于 1988 年至 2011 年。如果与综述主题相关且以英文发表，则选择这些论文。
