Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Neurol India. 2011 Sep-Oct;59(5):712-6. doi: 10.4103/0028-3886.86546.
Focused studies on sensory manifestations, especially pain and paresthesia in Guillain-Barre' (GB) syndrome are few and far between.
To study the sensory manifestations in GB syndrome during 10 days of hospitalization with clinico-electrophysiological correlation.
The study included 60 non-consecutive patients with GB syndrome, fulfilling National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) criteria for GB syndrome. Data especially related to clinical and electrophysiological evidence of sensory involvement were analyzed. Pain was assessed using a) visual analogue paraesthesias (Vapar), b) visual analogue for pain (Vap) and c) verbal rating scale for pain (Verp).
Sensory symptoms were widely prevalent: paraesthesia in 45 (75%) patients and pain in 30 (50%) patients. Impairment of different sensory modalities included: pain in 8 (13.3%), joint position sense in 14 (23.3%), and vibration in 11 (18.3%). Electrophysiological evidence of abnormal sensory nerve conduction was noted in 35 (58.3%) patients. Pain assessment using Vapar, Vap and Verp for from Day 1 to Day 10 of hospitalization revealed that from Day 7 onwards the degree and frequency of sensory symptoms and signs decreased. On comparing various clinico-electrophysiological parameters among patients of GB syndrome with and without pain and paresthesia. Presence of respiratory distress correlated with pain and paresthesia (P=0.02).
Sensory manifestations in GB syndrome are often under-recognized and under-emphasized. This study analyzed the evolution and the profile of pain and paresthesia in GB syndrome during hospitalization. Knowledge, especially about evolution of pain and paresthesia during hospitalization might improve understanding and patient care.
关于吉兰-巴雷综合征（GBS）的感觉表现，尤其是疼痛和感觉异常的集中研究很少。
通过临床电生理相关性研究，在住院 10 天内研究 GBS 中的感觉表现。
本研究纳入了 60 例非连续的吉兰-巴雷综合征患者，符合国家神经病学和通信障碍及中风研究所（NINCDS）的吉兰-巴雷综合征标准。分析了与临床和电生理感觉受累证据特别相关的数据。疼痛采用以下三种方法进行评估：a）感觉异常的视觉模拟评分（Vapar）、b）疼痛的视觉模拟评分（Vap）和 c）疼痛的口头评定量表（Verp）。
感觉症状广泛存在：感觉异常 45 例（75%），疼痛 30 例（50%）。不同感觉模式的损害包括：疼痛 8 例（13.3%）、关节位置觉 14 例（23.3%）、振动觉 11 例（18.3%）。35 例（58.3%）患者存在异常感觉神经传导的电生理证据。住院第 1 天至第 10 天的 Vapar、Vap 和 Verp 疼痛评估显示，从第 7 天开始，感觉症状和体征的程度和频率下降。在比较伴有和不伴有疼痛和感觉异常的 GBS 患者的各种临床电生理参数时，呼吸困难与疼痛和感觉异常相关（P=0.02）。
吉兰-巴雷综合征中的感觉表现经常被低估。本研究分析了住院期间吉兰-巴雷综合征中疼痛和感觉异常的演变和特征。了解疼痛和感觉异常在住院期间的演变可能会改善对患者的理解和护理。
