Chu G, Chang E, Patterson M
Department of Medicine, Stanford University School of Medicine, CA 94305.
Prog Clin Biol Res. 1990;340A:275-82.
Xeroderma pigmentosum (XP) is characterized by the defective excision repair of DNA damaged by many agents, including ultraviolet radiation (UV) and cisplatin. We have identified a factor in human cells that recognizes multiple forms of DNA damage and is absent in XP complementation group E. Denoted XPE binding factor, it is expressed at five-fold higher levels in tumor cell lines resistant to the antitumor drug cisplatin. Finally, although it does not have photoreactivating activity, XPE binding factor shares multiple binding characteristics with yeast photolyase, suggesting that it is the human homolog of photolyase.
着色性干皮病（XP）的特征是对多种因素（包括紫外线辐射（UV）和顺铂）造成的DNA损伤进行切除修复存在缺陷。我们在人类细胞中鉴定出一种因子，它能识别多种形式的DNA损伤，且在XP互补组E中不存在。该因子被称为XPE结合因子，在对抗肿瘤药物顺铂耐药的肿瘤细胞系中的表达水平高出五倍。最后，尽管XPE结合因子不具有光复活活性，但它与酵母光解酶具有多种结合特性，这表明它是光解酶的人类同源物。
Zotero 插件