肥胖、糖尿病和高血压与缓解期精神分裂症患者使用抗精神病药物有关。
Obesity, diabetes and hypertension associated with antipsychotic use in remitted schizophrenia.
作者信息
Saddichha Sahoo, Vishnuvardhan Gopalkrishnan, Akhtar Sayeed
机构信息
Senior Resident in Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
出版信息
Int J Risk Saf Med. 2011;23(3):181-5. doi: 10.3233/JRS-2011-0536.
OBJECTIVE
To ascertain the prevalence of diabetes, obesity and hypertension associated with antipsychotic use in remitted patients with schizophrenia.
METHODS
This study included a cross sectional survey of diabetes, obesity and hypertension among all remitted patients diagnosed with schizophrenia/schizoaffective disorder (n = 130) on at least 6 months of antipsychotic treatment.
RESULTS
A prevalence of 35.4% obesity, 1.5% hypertension and 3.8% (ADA) or 5.4% (WHO) prevalence of diabetes was observed.
CONCLUSIONS
The use of antipsychotic drugs in the long run may be associated with a significantly greater risk of developing obesity with moderate influence on development of diabetes and minimal to none on hypertension.
目的
确定精神分裂症缓解期患者使用抗精神病药物所致糖尿病、肥胖症和高血压的患病率。
方法
本研究对所有诊断为精神分裂症/分裂情感性障碍且接受至少6个月抗精神病药物治疗的缓解期患者（n = 130）进行了糖尿病、肥胖症和高血压的横断面调查。
结果
观察到肥胖症患病率为35.4%，高血压患病率为1.5%，糖尿病患病率为3.8%（美国糖尿病协会标准）或5.4%（世界卫生组织标准）。
结论
长期使用抗精神病药物可能会显著增加肥胖症的发病风险，对糖尿病发病有中度影响，对高血压发病影响极小或无影响。
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