Luo Wen, Li Mingwei, Luo Jing, He Yueming
Department of Rheumatology and Immunology, Capital Medical University, Beijing, China.
Hepatogastroenterology. 2012 May;59(115):747-50. doi: 10.5754/hge11465.
BACKGROUND/AIMS: To analyze the clinical characteristics of patients with mesenteric venous thrombosis related to autoimmune disease (AID).
Retrospective study of 5 AID patients with mesenteric vein thrombosis in a single hospital.
All 5 patients were female with an average age of 57.6 years. At the clinical visit all patients had clinical manifestations with signs of mesenteric blood vessel involvement and a significant increase of inflammatory markers. Surgical exploration identified peritonitis in all 5 cases - 2 cases of intestinal stenosis with mucosal ulcers and 3 cases of intestinal necrosis complicated by perforation. All 5 patients underwent partial bowel resection. Pathological examination confirmed chronic inflammation and vasculitis of intestinal connective tissue, combined with the formation of mesenteric vein thrombosis.
Mesenteric vein thrombosis is a serious complication of AID. AID patients with digestive tract symptoms should be screened by abdominal imaging. In addition to early hormonal therapy and immunosuppressant treatment of the primary disease, surgical treatment should be performed as soon as possible if the disease progresses.
背景/目的：分析与自身免疫性疾病（AID）相关的肠系膜静脉血栓形成患者的临床特征。
对一家医院的5例患有肠系膜静脉血栓形成的AID患者进行回顾性研究。
所有5例患者均为女性，平均年龄57.6岁。就诊时所有患者均有临床表现，伴有肠系膜血管受累体征及炎症标志物显著升高。手术探查发现所有5例均有腹膜炎——2例肠狭窄伴黏膜溃疡，3例肠坏死合并穿孔。所有5例患者均接受了部分肠切除术。病理检查证实肠道结缔组织存在慢性炎症和血管炎，并伴有肠系膜静脉血栓形成。
肠系膜静脉血栓形成是AID的严重并发症。有消化道症状的AID患者应进行腹部影像学筛查。除了对原发性疾病进行早期激素治疗和免疫抑制治疗外，如果病情进展，应尽快进行手术治疗。
