新型吡啶并吡嗪和嘧啶并噻嗪衍生物作为 FtsZ 抑制剂。
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.
机构信息
Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA.
出版信息
Bioorg Med Chem. 2011 Dec 1;19(23):7120-8. doi: 10.1016/j.bmc.2011.09.062. Epub 2011 Oct 5.
Abstract
A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity.
摘要
已经合成了一系列吡啶并吡嗪和嘧啶并噻嗪衍生物，并报道了它们对结核分枝杆菌（Mtb）FtsZ 的活性和对 Mtb H(37)Ra 和 Mtb H(37)Rv 的体外抗菌活性。本文所述的某些类似物表现出中等至良好的抑制活性。
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