Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, PR China.
Gene. 2012 Jan 10;491(2):110-5. doi: 10.1016/j.gene.2011.10.017. Epub 2011 Oct 15.
The calcium-sensing receptor (CaSR) is involved in maintaining calcium homeostasis via the regulation of parathyroid hormone (PTH) secretion. The associations between serum calcium concentrations, parathyroid hormone (PTH) level and CaSR polymorphism A986S have been studied, but results are inconsistent. Therefore, we performed a meta-analysis to clarify the role of this polymorphism on this topic. Weighted mean difference (WMD) and 95% confidence interval (CI) were calculated with random-effects model or fixed-effects model based on the heterogeneity analysis. Overall 2820, 1135 and 3149 healthy individuals were included for total calcium concentration, ionized calcium concentration and PTH level meta-analyses, respectively. Most of the individuals in this meta-analysis were healthy women. Healthy individuals with the AS+SS genotype had significantly higher total and ionized calcium concentrations than those with the AA genotype. However, there was no statistical significance concerning serum PTH level. The pooled WMD for total calcium concentration was 0.028 (95% CI: 0.012-0.045, P=0.001); for ionized calcium concentration was 0.016 (95% CI: 0.013-0.020, P<0.0001); and for PTH level was -0.027 (95% CI: -0.360-0.306, P=0.874). In conclusion, our meta-analysis indicates that the CaSR A986S polymorphism might be associated with total and ionized calcium concentrations in healthy individuals.
钙敏感受体（CaSR）通过调节甲状旁腺激素（PTH）的分泌来参与维持钙稳态。已经研究了血清钙浓度、甲状旁腺激素（PTH）水平与 CaSR 多态性 A986S 之间的关联，但结果不一致。因此，我们进行了一项荟萃分析，以阐明该多态性在这一主题上的作用。根据异质性分析，采用随机效应模型或固定效应模型计算加权均数差（WMD）和 95%置信区间（CI）。总共纳入了 2820、1135 和 3149 名健康个体进行总钙浓度、离子钙浓度和 PTH 水平的荟萃分析。该荟萃分析中的大多数个体是健康女性。与 AA 基因型相比，AS+SS 基因型的健康个体总钙和离子钙浓度显著升高。然而，血清 PTH 水平没有统计学意义。总钙浓度的合并 WMD 为 0.028（95%CI：0.012-0.045，P=0.001）；离子钙浓度为 0.016（95%CI：0.013-0.020，P<0.0001）；PTH 水平为-0.027（95%CI：-0.360-0.306，P=0.874）。总之，我们的荟萃分析表明，CaSR A986S 多态性可能与健康个体的总钙和离子钙浓度有关。
