Department of Biopharmacy, Galenic and Hospital Pharmacy, Universite Lille Nord de France, Lille, France.
Anesth Analg. 2012 Feb;114(2):328-32. doi: 10.1213/ANE.0b013e3182373a27. Epub 2011 Oct 24.
Stopping and resuming carrier fluid flow can lead to potentially dangerous transient disturbances in drug mass flow rate. We compared the impact of 2 infusion sets, one with very low dead-space volume and the other with greater dead-space volume, on the amount of drug delivered during stop-and-go carrier fluid flows.
Two infusion sets, both with antireflux, connected to an angiocatheter and with dead-space volumes of 6.185 mL and 0.071 mL, respectively, were assessed. Two protocols were studied: carrier fluid flow of 90 mL/h associated with noradrenaline infused at 7 mL/h and carrier fluid flow of 350 mL/h with a noradrenaline infusion flow of 65 mL/h. During both protocols, the carrier fluid was stopped and resumed at the same rate 30 minutes later. Effluent noradrenaline concentration was measured using UV spectrophotometry. Flow change efficiency was calculated from the ratio of the area under the experimental mass flow rate curve to the area under the theoretical instantaneous mass flow rate curve.
For both flow rate conditions, flow change efficiency was significantly different for the 2 infusion sets during the 10-minute period after stopping carrier fluid flow and the 10-minute period after restarting it. The major phenomena were sudden decreases in drug delivery after stopping carrier flow and sudden, temporary increases when it was resumed. The very low dead-space volume infusion set resulted in significant reduction in changes in drug delivery compared with the standard set, even at high flow rates.
The use of a very low dead-space volume set attenuates disturbances in drug delivery caused by interrupting and resuming carrier fluid flow.
停止和恢复输送液流可能会导致药物质量流速产生潜在危险的瞬态干扰。我们比较了两种输注套件，一种具有非常低的死腔体积，另一种具有较大的死腔体积，对停走式输送液流过程中输送的药物量的影响。
评估了两种输注套件，均具有防反流功能，分别连接到血管套管，死腔体积分别为 6.185 mL 和 0.071 mL。研究了两种方案：流速为 90 mL/h 的输送液流，与以 7 mL/h 输注的去甲肾上腺素相关联；流速为 350 mL/h 的输送液流，与以 65 mL/h 输注的去甲肾上腺素相关联。在这两种方案中，30 分钟后以相同的速率停止和恢复输送液流。使用紫外分光光度法测量流出的去甲肾上腺素浓度。通过实验质量流速曲线下面积与理论瞬时质量流速曲线下面积的比值计算流速变化效率。
对于两种流速条件，在停止输送液流后的 10 分钟和重新开始后的 10 分钟期间，两种输注套件的流速变化效率均有显著差异。主要现象是停止输送液流后药物输送突然减少，重新开始时突然暂时增加。与标准套件相比，低死腔体积输注套件在高流速下也显著减少了药物输送的变化。
使用低死腔体积套件可减轻中断和恢复输送液流引起的药物输送干扰。
