Guliev A B, Sidorenko B A, Lupanov V P, Krutovskikh I V, Iaroshevskaia F M
Kardiologiia. 1990 May;30(5):18-24.
Diltiazem, a new calcium antagonist, and metoprolol, a cardioselective beta-adrenoblocker, were comparatively studied in 53 patients with exertional angina and 11 patients with spontaneous angina. A simple blind random method using placebo, graded physical exercise test employing a bicycle ergometer, and Holter monitoring were applied to evaluate the efficiency of the antianginal treatment. A good antianginal effect was exhibited by the both drugs in exercise-induced angina. Diltiazem was found to be effective in 74% of the patients with exertional angina, whereas metoprolol was beneficial in 62%. Unlike diltiazem (85.7%), metoprolol (50.0%) was less potent in spontaneous angina.
对53例劳力性心绞痛患者和11例自发性心绞痛患者比较研究了新型钙拮抗剂地尔硫䓬和心脏选择性β-肾上腺素能阻滞剂美托洛尔。采用使用安慰剂的简单盲法随机方法、使用自行车测力计的分级体育锻炼试验以及动态心电图监测来评估抗心绞痛治疗的效果。两种药物在运动诱发的心绞痛中均显示出良好的抗心绞痛作用。地尔硫䓬在74%的劳力性心绞痛患者中有效，而美托洛尔在62%的患者中有益。与地尔硫䓬（85.7%）不同，美托洛尔在自发性心绞痛中的效力较低（50.0%）。
