Cha Sang Hee, Kim Hei Sung, Lee Jun Young, Kim Hyung Ok, Park Young Min
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Dermatol. 2011 Sep;23 Suppl 1(Suppl 1):S33-5. doi: 10.5021/ad.2011.23.S1.S33. Epub 2011 Sep 30.
A 69-year-old male presented with several painful erythematous patches on both palms and trunk several days after receiving iopromide (Ultravist®, Shering, Berlin, Germany). A fixed drug eruption (FDE) due to iopromide was suspected clinically. However, at that time, the patch test with iopromide at the lesion site gave negative results. Three years later, the patient was mistakenly administered iopromide again and patches with vesicles recurred on the same sites as well as on the genitalia. This episode was repeated once again after 1 year. In all episodes, the skin lesion resolved after application of topical steroids. Although a patch test with iopromide was negative in our case, we made a diagnosis of FDE due to iopromide because the skin lesions occurred again at the previously involved area after re-exposure to iopromide. To date, only three cases of FDE caused by non-ionic monomers have been documented in the English literature. Herein, we report on an interesting case of FDE caused by iopromide.
一名69岁男性在接受碘普罗胺（优维显®，先灵公司，柏林，德国）几天后，双手掌和躯干出现多处疼痛性红斑。临床怀疑为碘普罗胺所致的固定性药疹（FDE）。然而，当时在皮损部位进行的碘普罗胺斑贴试验结果为阴性。三年后，该患者再次误服碘普罗胺，相同部位以及生殖器部位再次出现有水疱的斑片。一年后这一情况再次出现。在所有发作过程中，局部应用类固醇后皮损均消退。尽管我们病例中的碘普罗胺斑贴试验为阴性，但我们仍诊断为碘普罗胺所致的FDE，因为再次接触碘普罗胺后，先前受累部位再次出现皮肤损害。迄今为止，英文文献中仅记载了3例由非离子单体引起的FDE。在此，我们报告一例由碘普罗胺引起的有趣的FDE病例。
