Department of Plastic Surgery, Institute of Reconstructive Plastic Surgery Laboratory, New York, New York, USA.
Tissue Eng Part B Rev. 2012 Aug;18(4):246-57. doi: 10.1089/ten.TEB.2011.0427. Epub 2012 Feb 15.
Bone repair and regeneration is a dynamic process that involves a complex interplay between the (1) ground substance, (2) cells, and (3) milieu. While each constituent is integral to the final product, it is often helpful to consider each component individually. Therefore, we created a two-part review to examine scaffolds and cells' roles in bone tissue engineering. In Part I, we review the myriad of materials use for in vivo bone engineering. In Part II, we discuss the variety cell types (e.g., osteocytes, osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and vasculogenic cells) that are seeded upon or recruited to these scaffolds. In Part III, we discuss the optimization of the microenvironment. The biochemical processes and sequence of events that guide matrix production, cellular activation, and ossification are vital to developing successful bone tissue engineering strategies and are thus succinctly reviewed herein.
骨修复和再生是一个动态的过程，涉及基质、细胞和细胞外环境之间的复杂相互作用。虽然每个组成部分对于最终产物都是不可或缺的，但通常有助于分别考虑每个成分。因此，我们撰写了这篇两部分的综述，以研究支架和细胞在骨组织工程中的作用。在第一部分中，我们回顾了用于体内骨工程的众多材料。在第二部分中，我们讨论了种在这些支架上或募集到这些支架上的各种细胞类型（例如，成骨细胞、破骨细胞、成骨细胞、软骨细胞、间充质干细胞和血管生成细胞）。在第三部分中，我们讨论了微环境的优化。指导基质产生、细胞激活和骨化的生化过程和事件序列对于开发成功的骨组织工程策略至关重要，因此本文对此进行了简要回顾。
