Department of Diagnostic Pathology, NTT Medical Center Tokyo, Higashigotanda, Shinagawa-ku, Tokyo, Japan.
Pathol Int. 2011 Nov;61(11):677-80. doi: 10.1111/j.1440-1827.2011.02719.x. Epub 2011 Aug 30.
We report a case of gastrointestinal stromal tumor (GIST) of the stomach mimicking extragastrointestinal origin. The tumor presented as a large isolated mass in the transverse mesocolon with a minor adhesion to the stomach. Microscopic examination revealed c-kit gene protein product (KIT)-positive tumor cells with epithelioid features. The tumor pseudocapsule close to the adhesion site included a small smooth muscle tissue component, indicating a gastric origin. Furthermore, tumor cells at the adhesion site showed prominent hyalinization and calcification. The tumor was diagnosed as a gastric GIST showing extensive extramural growth. Thus, GIST of the stomach and other parts of the gastrointestinal tract can present as tumors localized in the soft tissues of the abdomen mimicking extragastrointestinal origin.
我们报告了一例胃的胃肠道间质瘤（GIST），其表现为酷似源自胃肠道外的孤立性大肿块，与胃仅有轻微粘连。镜下可见 c-kit 基因蛋白产物（KIT）阳性的上皮样肿瘤细胞。靠近粘连部位的肿瘤假包膜包含一小部分平滑肌组织，提示胃来源。此外，粘连部位的肿瘤细胞有明显的玻璃样变和钙化。该肿瘤诊断为胃 GIST，表现为广泛的腔外生长。因此，胃和胃肠道其他部位的 GIST 可表现为位于腹部软组织内的局限性肿瘤，酷似源自胃肠道外。
