Peltier J, Lejeune J-P, Nicot B, Capel C, Baroncini M, Fichten A, Toussaint P, Desenclos C, Lefranc M, Le Gars D
Service de neurochirurgie, hôpital Nord, CHU d'Amiens, place Victor-Pachet, 80054 Amiens cedex 1, France.
Neurochirurgie. 2011 Sep-Dec;57(4-6):210-4. doi: 10.1016/j.neuchi.2011.09.018. Epub 2011 Oct 24.
Subependymoma is a benign lesion, slow-growing neoplasm, representing 0.2 to 0.7 % of intracranial tumors. They are often clinically silent, incidentally discovered at autopsy. These symptoms are related to big volume. They are attached to the septum pellucidum, leading to hydrocephalus by Monro foramen obstruction. Overall mean age at diagnosis is 39 years with more males than females. At CT-scan, subependymoma shows a slightly low attenuation compared to gray matter. There is no or mild enhancement following contrast injection. On MR T1-weighted imaging, subependymoma is isointense and hyperintense on MR T2-weighted imaging. Intramural calcifications and cystic components are noted in 20 to 30 % of patients. Peritumoral oedema is absent. Immunohistochemicals studies show intense positivity for S-100 and GFAP. The treatment is surgical with an excellent prognosis.
室管膜下瘤是一种良性病变,生长缓慢的肿瘤,占颅内肿瘤的0.2%至0.7%。它们通常在临床上无明显症状,多在尸检时偶然发现。这些症状与肿瘤体积较大有关。它们附着于透明隔,通过阻塞Monro孔导致脑积水。诊断时的总体平均年龄为39岁,男性多于女性。在CT扫描中,室管膜下瘤与灰质相比显示出略低的密度。注射造影剂后无强化或轻度强化。在磁共振T1加权成像上,室管膜下瘤呈等信号,在磁共振T2加权成像上呈高信号。20%至30%的患者可见壁内钙化和囊性成分。无瘤周水肿。免疫组织化学研究显示S-100和GFAP呈强阳性。治疗方法为手术,预后良好。