School of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston CH64 7TE, UK.
Vet J. 2012 Jun;192(3):467-71. doi: 10.1016/j.tvjl.2011.08.034. Epub 2011 Oct 24.
This study evaluated the use of sugammadex for reversal of profound neuromuscular blockade induced with rocuronium or vecuronium in dogs. Anaesthesia was induced and maintained with isoflurane in oxygen in eight dogs on two occasions. Neuromuscular blockade was monitored using peroneal nerve stimulation and acceleromyography. Rocuronium 0.6 mg/kg or vecuronium 0.1mg/kg was administered intravenously (IV), followed 5 min later by sugammadex 8 mg/kg IV. Lag and onset time of rocuronium and vecuronium, lag time from sugammadex injection to recovery of first twitch response, recovery of T1/T0 to 25% and 75%, recovery index, and time to recovery of the train-of-four ratio (T4/T1) to 0.9 were recorded. Cardiovascular and respiratory parameters were also noted. Statistical analysis was performed using one-way ANOVA. Onset time for rocuronium (37 ± 18s; [mean ± SD]) was significantly shorter than for vecuronium (62 ± 15s) (P<0.04). No other significant differences were found between the two groups. After both rocuronium and vecuronium blockade, T4/T1 recovered to 0.9 in under 2 min after sugammadex (58.1 ± 67.8s and 98.1 ± 70.3s, respectively; P<0.32). Sugammadex can reverse profound neuromuscular blockade induced by vecuronium or rocuronium safely and rapidly in isoflurane-anaesthetised dogs.
本研究评估了 sugammadex 在犬中用于逆转罗库溴铵或维库溴铵引起的深度神经肌肉阻滞。在两次麻醉中，8 只狗在氧气中的异氟烷下诱导和维持麻醉。使用腓肠神经刺激和加速度描记术监测神经肌肉阻滞。静脉注射罗库溴铵 0.6mg/kg 或维库溴铵 0.1mg/kg，5 分钟后静脉注射 sugammadex 8mg/kg。记录罗库溴铵和维库溴铵的潜伏期和起效时间、从 sugammadex 注射到恢复第一颤搐反应的潜伏期、恢复至 25%和 75%的 T1/T0、恢复指数以及恢复至四成比（T4/T1）的 0.9 的时间。还记录了心血管和呼吸参数。使用单因素方差分析进行统计分析。罗库溴铵的起效时间（37 ± 18s；[均值 ± SD]）明显短于维库溴铵（62 ± 15s）（P<0.04）。两组之间没有发现其他显著差异。在罗库溴铵和维库溴铵阻滞后，sugammadex 在 2 分钟内使 T4/T1 恢复至 0.9，分别为 58.1 ± 67.8s 和 98.1 ± 70.3s（P<0.32）。sugammadex 可安全、快速地逆转异氟烷麻醉犬中维库溴铵或罗库溴铵引起的深度神经肌肉阻滞。
