Wang Shengzi, Chen Fu, Li Ji, Zhang Haiyan, Zou Lifen, Wang Shuyi, Guo Ming, Yang Gang
Department of Radiation Oncology, Eye Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jul;25(14):636-40, 644.
To evaluate the therapeutic effect of malignant tumor of nasal cavity and sinus that based on modern radiotherapy.
Two hundred cases of malignant tumor of nasal cavity and sinus were retrospectively analyzed from 2004 to 2007. All the cases were location by CT simulator system and were treated with three dimensional conformal radiotherapy.
Among malignant tumor of nasal cavity and sinus, the incidence for locations was nasal cavity > maxillary sinus > ethmoid sinus > sphenoid sinus; the incidence for the type of pathology was squamous cell carcinoma > adenocarcinoma > olfactory neuroblastoma and olfactory esthesioneuroepithelioma > malignant melanoma > rhabdomyosarcoma; the incidence for general metastasis was rhabdomyosarcoma > malignant melanoma > adenocarcinoma, inverted papilloma and malignant changes > squamous cell carcinoma, olfactory neuroblastoma and olfactory esthesioneuroepithelioma. No severe radiation-related complication were found.
Clinical stage, pathological type were the important factors effecting the prognosis of patients with malignant tumor of nasal cavity and sinus. Three dimensional conformal radiotherapy based on CT simulator system could improve therapeutic effect and protect the normal tissue very well.
评估基于现代放疗的鼻腔及鼻窦恶性肿瘤的治疗效果。
回顾性分析2004年至2007年200例鼻腔及鼻窦恶性肿瘤患者。所有病例均通过CT模拟系统定位，并采用三维适形放疗。
在鼻腔及鼻窦恶性肿瘤中，发病部位发生率为鼻腔＞上颌窦＞筛窦＞蝶窦；病理类型发生率为鳞状细胞癌＞腺癌＞嗅神经母细胞瘤及嗅感觉神经上皮瘤＞恶性黑色素瘤＞横纹肌肉瘤；全身转移发生率为横纹肌肉瘤＞恶性黑色素瘤＞腺癌、内翻性乳头状瘤及恶变＞鳞状细胞癌、嗅神经母细胞瘤及嗅感觉神经上皮瘤。未发现严重的放疗相关并发症。
临床分期、病理类型是影响鼻腔及鼻窦恶性肿瘤患者预后的重要因素。基于CT模拟系统的三维适形放疗可提高治疗效果并很好地保护正常组织。
