Wietschel F, Malberg K
Abteilung für Medizinische Immunologie, Medizinischen Akademie Erfurt.
Allerg Immunol (Leipz). 1990;36(2):67-76.
Immune thrombocytopenia remains a diagnosis per exclusionem. There are no specific clinical symptoms or laboratory parameters to ensure diagnosis. In otherwise caused thrombocytopenias many authors found increased platelet-associated immunoglobin (PaIg) and platelet-binding serum immunoglobulin (PbSIg). Methods to determine PaIg and PbSIg are described and their clinical relevance is discussed. Determinations of PaIg and PbSIg with Ig-L-chain-specific ELISA are recommended. They improve diagnostic possibilities to distinguish ITP from nonimmune thrombocytopenias.
免疫性血小板减少症仍然是一种排除性诊断。没有特定的临床症状或实验室参数可确保做出诊断。在其他原因引起的血小板减少症中，许多作者发现血小板相关免疫球蛋白（PaIg）和血小板结合血清免疫球蛋白（PbSIg）增加。本文描述了测定PaIg和PbSIg的方法，并讨论了它们的临床相关性。推荐使用Ig轻链特异性酶联免疫吸附测定法（ELISA）来测定PaIg和PbSIg。它们提高了区分免疫性血小板减少性紫癜（ITP）与非免疫性血小板减少症的诊断可能性。
