Anal Chem. 2011 Dec 1;83(23):8863-6. doi: 10.1021/ac2024969. Epub 2011 Nov 8.
A novel ionization device for controlling the charge states of peptides based on an inductive elecrospray ionization technique was developed. This ion source keeps the major capabilities of electrospray ionization (ESI) which is compatible with liquid separation techniques (such as liquid chromatography (LC) and capillary electrophoresis (CE)) and can be potentially used to control the charge states of peptides accurately by simply varying the AC voltage applied. In comparison with conventional ESI, inductive ESI successfully simplifies the mass spectrum by reducing the charge states of peptide to a singly charged one, as well as eliminating the adduct ions.
一种基于感应电喷雾电离技术的新型离子化装置被开发出来，用于控制肽的荷电状态。这种离子源保留了电喷雾电离（ESI）的主要功能，与液体分离技术（如液相色谱（LC）和毛细管电泳（CE））兼容，并可以通过简单地改变施加的交流电压来潜在地精确控制肽的荷电状态。与传统的 ESI 相比，感应 ESI 通过将肽的荷电状态降低到单一电荷状态，以及消除加合物离子，成功地简化了质谱。
