环丙沙星与环孢素在骨髓移植受者中潜在相互作用的研究。
Investigation of potential interaction of ciprofloxacin with cyclosporine in bone marrow transplant recipients.
作者信息
Krüger H U, Schuler U, Proksch B, Göbel M, Ehninger G
机构信息
Department of Internal Medicine II, University Hospital Tübingen, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1990 Jun;34(6):1048-52. doi: 10.1128/AAC.34.6.1048.
Abstract
The effect of the 4-quinolone antimicrobial agent ciprofloxacin on the concentration in plasma and the pharmacokinetics of the immunosuppressive agent cyclosporine was studied in 10 bone marrow transplant recipients. There were no statistically or clinically significant changes in cyclosporine trough concentrations or areas under the concentration-time curve following oral doses of 500 mg of ciprofloxacin every 12 h for 4 days. The data suggest a lack of relevant pharmacokinetic interaction of ciprofloxacin with cyclosporine. There was no indication of an enhanced nephrotoxicity for this drug combination.
摘要
在10名骨髓移植受者中研究了4-喹诺酮类抗菌药物环丙沙星对免疫抑制剂环孢素血浆浓度及药代动力学的影响。每12小时口服500mg环丙沙星，持续4天，之后环孢素的谷浓度或浓度-时间曲线下面积没有统计学或临床意义上的显著变化。数据表明环丙沙星与环孢素之间缺乏相关的药代动力学相互作用。没有迹象表明该药物组合的肾毒性增强。
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本文引用的文献
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Antimicrob Agents Chemother. 1984 Nov;26(5):741-4. doi: 10.1128/AAC.26.5.741.
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Cyclosporine A: a clinical evaluation of drug interactions.
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Determination of ciprofloxacin and its 7-ethylenediamine metabolite in human serum and urine by high-performance liquid chromatography.高效液相色谱法测定人血清和尿液中环丙沙星及其7-乙二胺代谢物
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Pharmacokinetics of ciprofloxacin: intravenous and increasing oral doses.环丙沙星的药代动力学：静脉注射及递增口服剂量
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Clinical pharmacokinetics of cyclosporin.环孢素的临床药代动力学
Clin Pharmacokinet. 1986 Mar-Apr;11(2):107-32. doi: 10.2165/00003088-198611020-00002.
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Cyclosporine drug interactions: a review.环孢素的药物相互作用：综述
Ther Drug Monit. 1987 Dec;9(4):399-406. doi: 10.1097/00007691-198712000-00007.
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Possible interaction of ciprofloxacin with cyclosporin A.环丙沙星与环孢素A之间可能存在的相互作用。
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