Turan Hakan, Kaya Ertugrul, Gurlevik Zehra, Erdem Havva, Oktay Murat
Duzce University Medical Faculty, Department of Dermatology, 81000, Duzce, Turkey.
Cutan Ocul Toxicol. 2012 Jun;31(2):148-50. doi: 10.3109/15569527.2011.627077. Epub 2011 Oct 28.
Cetuximab is an epidermal growth factor receptor inhibitor used in metastatic colorectal cancer, and head and neck cancers. Several cutaneous side effects due to cetuximab such as acne-like rash, pruritus, dry skin, desquamation, hypertrichosis, and paronychia have been reported so far. A 59-year-old male patient with metastatic colon cancer referred to our outpatient clinic for his lesions on the dorsal surfaces of his hands and wrists, and on thighs developing after the chemotherapy. He was diagnosed as neutrophilic eccrine hydradenitis related to cetuximab in the light of clinical and histopathological findings. According to our knowledge, this is the first reported case of neutrophilic ecrine hydradenitis due to cetuximab.
西妥昔单抗是一种用于转移性结直肠癌和头颈癌的表皮生长因子受体抑制剂。迄今为止，已报告了西妥昔单抗引起的几种皮肤副作用，如痤疮样皮疹、瘙痒、皮肤干燥、脱屑、多毛症和甲沟炎。一名59岁的男性转移性结肠癌患者因化疗后双手和手腕背部以及大腿出现病变而转诊至我们的门诊。根据临床和组织病理学检查结果，他被诊断为与西妥昔单抗相关的嗜中性小汗腺炎。据我们所知，这是首例因西妥昔单抗导致嗜中性小汗腺炎的报告病例。
