Center of Reproductive Medicine and Biology, Hôpital Antoine Béclère, University Paris-Sud, and INSERM, U782, Clamart.
Fertil Steril. 2011 Nov;96(5):1062-5. doi: 10.1016/j.fertnstert.2011.09.050.
To review and summarize data from the scientific literature on the use of androgens to improve ovarian function.
Review of pertinent literature.
University hospital.
PATIENT(S): Women exposed to androgens.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Critical review of the literature.
RESULT(S): The artificial increase of intra-ovarian androgen concentrations constitutes an attractive concept for improving the deficient ovarian function of poor responders. Data from studies conducted in animals treated with high-dose androgens, together with observations made in hyperandrogenic women or female-to-male transsexuals receiving virilizing androgen doses, indicate that androgens may increase follicle responsiveness to FSH and/or the number of growing follicles in the ovary. Yet, definite clinical demonstration of such a concept still is not available.
CONCLUSION(S): Current clinical approaches aiming at increasing androgen availability in the ovary showed conflicting results. Therefore, additional studies using proper strategies to achieving higher intra-ovarian androgen concentrations for longer intervals are required to define the clinical efficiency of androgens in poor responders.
回顾和总结雄激素在改善卵巢功能方面的科学文献数据。
相关文献回顾。
大学医院。
接触雄激素的女性。
无。
文献的批判性评价。
人为增加卵巢内雄激素浓度是改善卵巢低反应患者卵巢功能不足的一个有吸引力的概念。用大剂量雄激素处理动物的研究数据，以及对高雄激素女性或接受雄性化雄激素剂量的女性-男性易性者的观察结果表明，雄激素可能增加卵泡对 FSH 的反应性和/或卵巢中生长卵泡的数量。然而，这一概念的确切临床证据尚不可用。
目前旨在增加卵巢内雄激素可用性的临床方法显示出相互矛盾的结果。因此，需要使用适当的策略来提高更长时间内卵巢内雄激素的浓度，以确定雄激素在卵巢低反应者中的临床疗效。
