秘鲁女性浸润性宫颈癌组织病理学特异性发病率的地域差异。

Regional variation in histopathology-specific incidence of invasive cervical cancer among Peruvian women.

机构信息

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA.

出版信息

Int J Gynaecol Obstet. 2012 Jan;116(1):47-51. doi: 10.1016/j.ijgo.2011.08.008. Epub 2011 Oct 27.

DOI:10.1016/j.ijgo.2011.08.008

PMID:22036058

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3641528/

Abstract

OBJECTIVE

To evaluate patterns of cervical cancer incidence in Peru by examining variation in 2 common histopathologic types, squamous cell carcinoma (SCC) and adenocarcinoma (ADC), and analyzing trends over time.

METHODS

Data on the incidence of invasive cervical cancer between 1984 and 2006 were obtained from 3 population-based cancer registries in Peru: Lima, Trujillo, and Arequipa. For each registry, data quality assessment was performed, crude and age-specific incidence was calculated, and time trends were analyzed.

RESULTS

Overall and SCC incidence varied across registries but incidence of ADC did not. Overall and SCC incidence showed significant declines in Trujillo (P<0.05) and modest declines in Lima (P>0.05) over time. ADC incidence showed marginally significant increases among women aged 15-29 years in Trujillo (P=0.10) and modest increases among young women in Lima (P>0.05).

CONCLUSION

Population-based cancer registries were an efficient source of data for evaluating the incidence of cervical cancer once data quality had been established. Geographic and temporal variations in cervical cancer burden were documented in Peru. The trends suggest that cervical ADC is increasing among young women in urban Peru, particularly in Trujillo. We recommend supplementing current Papanicolaou test screening with complementary methods of cervical cancer control, including human papillomavirus (HPV) vaccination and HPV DNA testing.

摘要

目的

通过检查两种常见组织病理学类型（鳞状细胞癌[SCC]和腺癌[ADC]）的发病模式，分析秘鲁宫颈癌发病率的变化趋势。

方法

从秘鲁 3 个基于人群的癌症登记处（利马、特鲁希略和阿雷基帕）获得了 1984 年至 2006 年浸润性宫颈癌的发病率数据。对每个登记处进行了数据质量评估，计算了粗发病率和年龄别发病率，并分析了时间趋势。

结果

总体发病率和 SCC 发病率在各登记处之间存在差异，但 ADC 发病率没有差异。特鲁希略的总体发病率和 SCC 发病率呈显著下降趋势（P<0.05），而利马的发病率呈适度下降趋势（P>0.05）。特鲁希略 15-29 岁年龄段的妇女中 ADC 发病率呈边缘性显著上升趋势（P=0.10），利马年轻妇女的发病率呈适度上升趋势（P>0.05）。

结论

在建立数据质量后，基于人群的癌症登记处是评估宫颈癌发病率的有效数据来源。本研究记录了秘鲁宫颈癌负担的地域和时间变化。这些趋势表明，在秘鲁城市年轻妇女中，宫颈癌 ADC 呈上升趋势，尤其是在特鲁希略。我们建议在目前巴氏涂片检查筛查的基础上，补充宫颈癌控制的其他方法，包括人乳头瘤病毒（HPV）疫苗接种和 HPV DNA 检测。