Peck Mogammad Thabit, Stephen Lawrence X G, Marnewick Johan, Majeed Abdul
Department of Oral Medicine and Periodontology, University of the Western Cape, Private Bag X1, Tygerberg 7505, Cape Town, South Africa.
Trop Doct. 2012 Jan;42(1):52-3. doi: 10.1258/td.2011.110240. Epub 2011 Oct 28.
Tuberculosis (TB) is one of the leading casues of morbidity and death in a number of countries worldwide. A healthy 42-year-old patient presented with a chronic palatal ulcer that was not responsive to routine antibiotic treatment. A biopsy and further systemic investigation revealed a diagnosis of TB. An eight-month extended course of oral rifampin and isoniazid was instituted successfully resulting in complete resolution of symptoms. It is important that clinicians be aware that chronic oral ulcerations may be the first sign of systemic disease. A biopsy should therefore be mandatory for any chronic oral ulcer not responsive to conventional treatment.
结核病（TB）是全球许多国家发病和死亡的主要原因之一。一名42岁健康患者出现慢性腭部溃疡，对常规抗生素治疗无反应。活检及进一步的全身检查显示诊断为结核病。成功实施了为期八个月的口服利福平和异烟肼延长疗程，症状完全缓解。临床医生应意识到慢性口腔溃疡可能是全身性疾病的首发症状，因此，对于任何对传统治疗无反应的慢性口腔溃疡，活检应是强制性的。
