Rasmussen O, Gregersen S, Hermansen K
Second University Clinic of Internal Medicine, Aarhus Kommunehospital, Denmark.
J Intern Med. 1990 Aug;228(2):97-101. doi: 10.1111/j.1365-2796.1990.tb00201.x.
To evaluate the predictive capability of the postprandial blood glucose response after consumption of a starch-rich meal, we compared the glycaemic effects of spaghetti (60 g) taken alone and with bolognese sauce (167 g). The study was carried out in both NIDDM (n = 6) and IDDM (n = 6) subjects. The latter had achieved normoglycaemia 120 min prior to the test meal by means of an artificial pancreas (Biostator) which provided constant insulinaemia during the observation period of 4 h. We found that the areas of blood glucose (above basal) were identical irrespective of whether spaghetti was taken alone or as part of a mixed meal in both NIDDM (484 +/- 154 mmol l-1 240 min-1 vs. 393 +/- 126 mmol l-1 240 min-1) and IDDM subjects (610 +/- 143 mmol l-1 240 min-1 vs. 770 +/- 135 mmol l-1 240 min-1). The insulin levels were identical in the IDDM diabetics. By contrast, the mixed meal caused a more marked insulinaemic response than spaghetti per se in the NIDDM subjects (3187 +/- 637 mU l-1 240 min-1 vs. 1940 +/- 235 mU l-1 240 min-1; P less than 0.05). In conclusion, the predictive capability of the glycaemic response to spaghetti was good in both IDDM and NIDDM diabetic subjects, at least under the conditions of the present study.
为评估摄入富含淀粉餐食后餐后血糖反应的预测能力，我们比较了单独食用意大利面（60克）和搭配肉酱（167克）时的血糖效应。该研究在非胰岛素依赖型糖尿病（NIDDM，n = 6）和胰岛素依赖型糖尿病（IDDM，n = 6）患者中进行。后者在试验餐进食前120分钟通过人工胰腺（Biostator）实现血糖正常，该人工胰腺在4小时观察期内提供恒定的胰岛素水平。我们发现，无论意大利面是单独食用还是作为混合餐的一部分，NIDDM患者（484±154 mmol·l⁻¹·240分钟⁻¹对393±126 mmol·l⁻¹·240分钟⁻¹）和IDDM患者（610±143 mmol·l⁻¹·240分钟⁻¹对770±135 mmol·l⁻¹·240分钟⁻¹）的血糖（高于基础值）面积相同。IDDM糖尿病患者的胰岛素水平相同。相比之下，混合餐在NIDDM患者中引起的胰岛素反应比意大利面本身更明显（3187±637 mU·l⁻¹·240分钟⁻¹对1940±235 mU·l⁻¹·240分钟⁻¹；P<0.05）。总之，至少在本研究条件下，IDDM和NIDDM糖尿病患者对意大利面血糖反应的预测能力良好。
