Choura Mouna, Rebaï Ahmed
Molecular and Cellular Diagnosis Processes, Centre of Biotechnology of Sfax, University of Sfax , Route Sidi Mansour, Sfax , Tunisia.
J Recept Signal Transduct Res. 2011 Dec;31(6):387-94. doi: 10.3109/10799893.2011.625425. Epub 2011 Oct 31.
Receptor tyrosine kinases (RTKs) are transmembrane proteins involved in the control of fundamental cellular processes in metazoans. RTKs possess a general structure that includes an extracellular domain, a transmembrane domain and a highly conserved tyrosine kinase domain. RTKs are classified according to their variable extracellular ligand-binding domain. Studies of human RTK members have yielded a wealth of information elucidating their importance. Improper functioning of these enzymes due to mutations, mainly in the kinase domain, is often manifested in various human diseases and is known to be involved in several types of cancer. Here we summarize most of human RTKs, their cognate ligands, as well as related diseases and discuss the eventual use of certain RTKs as new therapeutic targets.
受体酪氨酸激酶（RTKs）是参与后生动物基本细胞过程调控的跨膜蛋白。RTKs具有一个包括细胞外结构域、跨膜结构域和高度保守的酪氨酸激酶结构域的一般结构。RTKs根据其可变的细胞外配体结合结构域进行分类。对人类RTK成员的研究已经产生了大量阐明其重要性的信息。这些酶由于突变（主要在激酶结构域）而功能异常，常常在各种人类疾病中表现出来，并且已知与几种类型的癌症有关。在这里，我们总结了大多数人类RTKs、它们的同源配体以及相关疾病，并讨论了将某些RTKs最终用作新治疗靶点的情况。
