Brittain H G
Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey 08903.
Pharm Res. 1990 Jul;7(7):683-90. doi: 10.1023/a:1015851118787.
The molecular chirality associated with an optically active molecule is manifested in the bulk crystallography of the compound. The historical development of optical activity was greatly aided by systematic studies of the habits of enantiomorphic crystals. The concepts of molecular dissymmetry, crystallography, and chirality are therefore linked. Racemic materials can be characterized by means of their melting-point phase diagrams, and this information used to design rational separations of racemic mixtures into their component enantiomers. Certain compounds are found to resolve spontaneously upon crystallization, and the enantiomers of these conglomerate species may be separated by direct crystallization. Compounds which crystallize as true racemates require resolution through the formation and separation of dissociable diastereomer species. The choice of resolution pathway is therefore determinable through an evaluation of the melting-point phase diagrams. When possible, resolution through direct crystallization represents the simplest, most cost-effective means of enantiomer resolution.
与旋光活性分子相关的分子手性在该化合物的体晶体学中得以体现。对映晶体习性的系统研究极大地推动了旋光活性的历史发展。因此，分子不对称性、晶体学和手性的概念相互关联。外消旋材料可通过其熔点相图来表征，并且该信息可用于设计将外消旋混合物合理分离成其对映体组分的方法。发现某些化合物在结晶时会自发拆分，这些聚集体物种的对映体可通过直接结晶分离。以真正外消旋体形式结晶的化合物需要通过形成和分离可解离的非对映体物种来拆分。因此，通过评估熔点相图可以确定拆分途径的选择。在可能的情况下，通过直接结晶进行拆分是对映体拆分最简单、最具成本效益的方法。
