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[一名接受抗精神病药物治疗的年轻患者发生嗜酸性粒细胞性心肌炎与意外猝死]

[Eosinophilic myocarditis and sudden unexpected death in a younger patient treated with antipsychotics].

作者信息

Christoffersen Rikke Kjærgaard, Vestergård Lone Due, Høimark Lene, Vesterby Annie

机构信息

Retspatologisk Afdeling, Retsmedicinsk Institut, Aarhus Universitet, 8200 Aarhus N, Denmark.

出版信息

Ugeskr Laeger. 2011 Oct 31;173(44):2799-800.

PMID:22040663
Abstract

A 36 year-old man suffering from schizophrenia was found dead in his apartment. Forensic autopsy was performed due to sudden unexpected death but did not yield the cause of death. Histological examination of the heart showed eosinophilic myocarditis (EM) while forensic chemistry showed a raised level of aripripazol. We discuss the risk of sudden cardiac death in patients receiving antipsychotic drugs and the possible connection between raised drug levels and EM, and we emphasise the importance of autopsy and hope for better means in the future of finding patients at risk.

摘要

一名36岁的精神分裂症男子被发现死于其公寓内。因突然意外死亡进行了法医尸检,但未查明死因。心脏组织学检查显示为嗜酸性粒细胞性心肌炎(EM),而法医化学检测显示阿立哌唑水平升高。我们讨论了接受抗精神病药物治疗的患者发生心源性猝死的风险以及药物水平升高与EM之间的可能联系,并强调了尸检的重要性,同时期望未来能有更好的方法来发现有风险的患者。

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