Research and Development Division, Nichirei Foods Inc., Chiba, Japan.
Biol Pharm Bull. 2011;34(11):1744-7. doi: 10.1248/bpb.34.1744.
It has been suggested that some food components, such as bioflavonoids, affect the bioavailability of ascorbic acid in humans. Since little is known in Japan about the effective intake of this dietary requirement, we tested young Japanese males after the ingestion of commercial ascorbic acid or acerola (Malpighia emarginata DC.) juice to compare the quantities absorbed and excreted. Healthy Japanese subjects received a single oral dose of ascorbic acid solution (50, 100, 200 or 500 mg) and received distilled water as a reference at intervals of 14 d or longer. All subjects were collected blood and urine until 6 h after ingestion and evaluated for time-dependent changes in plasma and urinary ascorbic acid levels. Predictably, the area under the curve (AUC) values in plasma and urine after ingestion increased dose-dependently. Next, each subject received diluted acerola juice containing 50 mg ascorbic acid. Likewise, their plasma and urinary ascorbic acid concentrations were measured. In plasma, the AUC value of ascorbic acid after ingestion of acerola juice tended to be higher than that from ascorbic acid alone. In contrast, the urinary excretion of ascorbic acid at 1, 2 and 5 h after ingestion of acerola juice were significantly less than that of ascorbic acid. These results indicate that some component of acerola juice favorably affected the absorption and excretion of ascorbic acid.
有人提出，某些食物成分，如生物类黄酮，会影响人体对维生素 C 的生物利用度。由于日本人对这种饮食需求的有效摄入量知之甚少，因此我们在摄入商业维生素 C 或樱桃（Malpighia emarginata DC.）汁后对年轻的日本男性进行了测试，以比较吸收和排泄的量。健康的日本受试者单次口服维生素 C 溶液（50、100、200 或 500mg），并在 14 天或更长时间间隔内以蒸馏水作为对照。所有受试者在摄入后 6 小时内采集血液和尿液，并评估血浆和尿液中维生素 C 水平随时间的变化。可以预见的是，摄入后血浆和尿液中的曲线下面积（AUC）值呈剂量依赖性增加。接下来，每个受试者都接受了含有 50mg 维生素 C 的稀释樱桃汁。同样，测量了他们的血浆和尿液中的维生素 C 浓度。在血浆中，摄入樱桃汁后的 AUC 值似乎高于单独摄入维生素 C 的 AUC 值。相比之下，摄入樱桃汁后 1、2 和 5 小时的尿液中维生素 C 的排泄量明显少于维生素 C。这些结果表明，樱桃汁中的某些成分有利于维生素 C 的吸收和排泄。
