Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA.
J Int Neuropsychol Soc. 2011 Nov;17(6):986-97. doi: 10.1017/S1355617711001093.
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, resulting in physical, cognitive and affective disturbances, with notable declines in the ability to learn and retain new information. In this study, we examined if higher levels of physical activity in MS individuals were associated with an increased resting-state connectivity of the hippocampus and cortex, resulting in better performance on a task of episodic memory. Forty-five individuals with a clinically definite diagnosis of MS were recruited for the study. Consistent with previous reports, hippocampus was functionally connected to the posteromedial cortex, parahippocampal gyrus, superior frontal gyrus, and the medial frontal cortex. Higher levels of physical activity in MS patients were associated with an increased coherence between the hippocampus and the posteromedial cortex (PMC). The increased connectivity between these two regions, in turn, was predictive of better relational memory, such that MS patients who showed an increased coherence between the left (not right) hippocampus and the PMC also showed better relational memory. Results of the study are interpreted in light of the challenge of disentangling effects of physical activity from effects of disease severity and its neuropathological correlates.
多发性硬化症 (MS) 是一种中枢神经系统的炎症性疾病，导致身体、认知和情感障碍，学习和保留新信息的能力明显下降。在这项研究中，我们研究了多发性硬化症患者较高水平的身体活动是否与海马体和皮层的静息状态连接增加有关，从而提高情景记忆任务的表现。招募了 45 名临床确诊的多发性硬化症患者参加这项研究。与先前的报告一致，海马体与后内侧皮层、海马旁回、额上回和额内侧回有功能连接。多发性硬化症患者较高的身体活动水平与海马体和后内侧皮层（PMC）之间的相干性增加有关。这两个区域之间的连接增加反过来又预示着更好的关系记忆，即左（非右）海马体与 PMC 之间的相干性增加的多发性硬化症患者也表现出更好的关系记忆。该研究的结果是根据从疾病严重程度及其神经病理学相关性中分离出身体活动影响的挑战来解释的。
