Reventós J, Hammond G L, Musto N A, Bardin C W
Population Council Rockefeller University, New York, NY 10021.
Rev Esp Fisiol. 1990 Mar;46(1):9-16.
Steroid binding proteins bind steroid hormones with high affinity and their function is to carry those hormones in the extracellular compartment. Since their discovery more than fifty years ago, many reports concerning their physicochemical structures and functions have contributed to the better understanding of those proteins. Recent advances in recombinant DNA technology have led to the availability of molecular probes for these proteins, and new approaches have been used to analyse their gene structures as well as the regulation of their synthesis. In the present report, we will review the new findings of the last five years which include the cloning and sequencing of the cDNAs and genes for corticosteroid binding globulin, testosterone estradiol binding globulin and androgen binding protein, as well as the tissue distribution and regulation of their mRNAs in normal tissues and cancer cell lines.
类固醇结合蛋白以高亲和力结合类固醇激素，其功能是在细胞外区室中运载这些激素。自五十多年前被发现以来，许多关于其物理化学结构和功能的报告有助于更好地理解这些蛋白质。重组DNA技术的最新进展使得能够获得针对这些蛋白质的分子探针，并且已采用新方法来分析它们的基因结构以及合成调控。在本报告中，我们将综述过去五年的新发现，包括皮质类固醇结合球蛋白、睾酮雌二醇结合球蛋白和雄激素结合蛋白的cDNA和基因的克隆与测序，以及它们的mRNA在正常组织和癌细胞系中的组织分布和调控。
