Collier Anderson B, Simpson Lesley, Monteleone Philip
Department of Pediatrics, Lehigh Valley Hospital Health Network, University of South Florida College of Medicine, Bethlehem, PA, USA.
J Pediatr Hematol Oncol. 2011 Dec;33(8):631-4. doi: 10.1097/MPH.0b013e31821b234d.
Cutaneous Ewing sarcoma is a rare variant that has been poorly characterized and has no standard therapy. We report 2 patients with cutaneous Ewing sarcoma and review 76 other cases reported in the literature for demographics, presentation, treatment, and outcome. Only 2 patients presented with metastatic disease, and only 8 patients developed metastatic disease. Ninety-one percent of all patients are alive despite wide variations in treatment regimens. On the basis of this summary, treatment consisting of local control with surgery and/or radiation and abbreviated chemotherapy is proposed as a treatment option for this less aggressive Ewing sarcoma.
皮肤尤文肉瘤是一种罕见的变异型，其特征描述不足且尚无标准治疗方法。我们报告了2例皮肤尤文肉瘤患者，并回顾了文献中报道的其他76例病例的人口统计学、临床表现、治疗及预后情况。仅有2例患者就诊时即有转移性疾病，仅有8例患者出现转移性疾病。尽管治疗方案差异很大，但所有患者中有91%仍然存活。基于这一总结，对于这种侵袭性较低的尤文肉瘤，建议采用手术和/或放疗进行局部控制并联合短程化疗的治疗方案。
