Department of Pathology, Biogen Idec Hemophilia, 9 Fourth Avenue, Waltham, MA 02451 2, USA.
Cancer Metastasis Rev. 2011 Dec;30(3-4):613-8. doi: 10.1007/s10555-011-9309-9.
Hypoxia is a pathological hallmark feature of solid tumors. Though hypoxia is an adverse physiological state, tumors have evolved to utilize this unsuitable environment to their own advantage by activating key biochemical and cellular pathways that are important in progression, survival, and metastasis. Several studies have emphasized the importance of lipid mediators in regulating key biomolecules in the hypoxic microenvironment, for example hypoxia inducible factor-1 (HIF-1), the master regulator of hypoxia. Lipid mediators have been reported to enhance the levels and activity of HIF-1, which subsequently signal to stimulate angiogenesis and tumor cell survival under hypoxic conditions. There are also reports of hypoxia and HIF-1 enhancing the levels of some lipid mediators mostly by upregulating the levels of the enzymes responsible for their biosynthesis. This review gives a brief overview of these two mechanisms and the role played by bioactive lipid mediators in the regulation of tumor progression and survival under hypoxia.
缺氧是实体肿瘤的病理标志特征。尽管缺氧是一种不利的生理状态，但肿瘤已经进化到利用这种不适宜的环境来为自己谋利，激活关键的生化和细胞途径，这些途径在肿瘤的进展、存活和转移中非常重要。有几项研究强调了脂质介质在调节缺氧微环境中的关键生物分子（例如缺氧诱导因子-1（HIF-1））中的重要性，HIF-1 是缺氧的主要调节因子。据报道，脂质介质可以增强 HIF-1 的水平和活性，随后信号刺激在缺氧条件下促进血管生成和肿瘤细胞存活。也有报道称，缺氧和 HIF-1 通过上调负责其生物合成的酶的水平来增强一些脂质介质的水平。这篇综述简要概述了这两种机制以及生物活性脂质介质在缺氧条件下调节肿瘤进展和存活中的作用。
