Karami Ali, Ghanei Mostafa, Alaeddini Farshid, Soltanpour Mohammad Javad, Yassini Mobin, Harandi Ali Amini
Oman Med J. 2011 Mar;26(2):118-21. doi: 10.5001/omj.2011.29.
To determine the levels of vascular endothelial growth factor isoform consisting of 165 amino acids (VEGF165) in Bronchoalveolar Lavage Fluid from Mustard Exposed Patients.
Bronchoscopy with Bronchoalveolar Lavage was performed on sulphur mustard exposed patients. A total of 39 patients with documented exposure to Sulfur Mustard during the Iran-Iraq war participated in this study, of which 38 patients were males and one patient was female.
The mean±SD age of patients was 41 ± 6.6 years. The mean time after exposure to sulfur mustard was 19 ±1.7 years. Eighteen patients had concomitant war injuries but they were not related to the respiratory system. While Twenty-two patients had a history of submassive persistent hemoptysis. There was no case with massive hemoptysis. Most of the patients had small airway obstruction (FEV1/FVC% = 78.14 ± 9.76 and FEV1% =82.79±18.23). Twenty-three patients had significant air trapping in the chest. High Resolution Computed Tomography was compatible with BOS. VEGF165 concentrations in BALF were 36.87 ± 34.68 pg/ml. When corrected to total protein of Bronchoalveolar Lavage Fluid (BALF) it was 0.76 ± 0.70 pg/mg. BALF of VEGF did not correlate with hemoptysis or air trapping in chest HRCT. Thus, there was also no correlation between level of VEGF165 in BALF and any of PFT indexes (FVC, FEV1, MMEF or PEF).
Although VEGF is one of the cytokines which has an important role in chronic pulmonary disorders, it seems that it has no essential role in the severity of Mustard Lung Disease.
测定芥子气暴露患者支气管肺泡灌洗液中由165个氨基酸组成的血管内皮生长因子异构体（VEGF165）水平。
对芥子气暴露患者进行支气管镜下支气管肺泡灌洗。共有39例在两伊战争期间有芥子气暴露记录的患者参与本研究，其中38例为男性，1例为女性。
患者的平均年龄±标准差为41±6.6岁。暴露于芥子气后的平均时间为19±1.7年。18例患者有战争相关损伤，但与呼吸系统无关。22例患者有亚大量持续性咯血病史。无大量咯血病例。大多数患者有小气道阻塞（FEV1/FVC% = 78.14±9.76，FEV1% = 82.79±18.23）。23例患者胸部有明显气体潴留。高分辨率计算机断层扫描与闭塞性细支气管炎综合征相符。支气管肺泡灌洗液中VEGF165浓度为36.87±34.68 pg/ml。校正支气管肺泡灌洗液（BALF）总蛋白后为0.76±0.70 pg/mg。BALF中VEGF与咯血或胸部HRCT气体潴留无关。因此，BALF中VEGF165水平与任何肺功能指标（FVC、FEV1、MMEF或PEF）均无相关性。
尽管VEGF是在慢性肺部疾病中起重要作用的细胞因子之一，但似乎它在芥子气肺病的严重程度方面没有关键作用。
