College of Bioengineering, Chongqing University, Shazheng Street No.174. Shapingba, Chongqing 400030, People's Republic of China.
Future Oncol. 2011 Nov;7(11):1347-57. doi: 10.2217/fon.11.109.
Although drug-delivery systems have been developed to improve drug biodistribution and efficiency in cancer therapy, some limitations still hinder successful drug targeting and delivery. Multiple drugs in combination seems a promising strategy for cancer therapy. It enables drugs to be delivered to multiple targets and exhibits the additive or synergistic effects of drugs. Physiological barriers are known to be the main obstacles of insufficient drug efficacy and delivery in tumors, but they are likely to be potential targets in combination therapy as well. This article discusses some general considerations for optimizing multiply drug delivery, including drug-release profiles and loading strategies.
尽管已经开发了药物输送系统来提高癌症治疗中药物的生物分布和效率，但一些限制因素仍然阻碍了药物的成功靶向和输送。联合使用多种药物似乎是癌症治疗的一种有前途的策略。它使药物能够递送到多个靶点，并表现出药物的相加或协同作用。众所周知，生理屏障是肿瘤中药物疗效和输送不足的主要障碍，但它们也可能是联合治疗的潜在靶点。本文讨论了优化多药物输送的一些一般考虑因素，包括药物释放谱和加载策略。
