Department of Clinical Care and Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado, USA.
J Aerosol Med Pulm Drug Deliv. 2012 Feb;25(1):1-6. doi: 10.1089/jamp.2011.0901. Epub 2011 Nov 1.
This project designed and tested an economical apparatus to safely expose guinea pigs to biohazardous aerosol. The goals were to design a system that can be easily decontaminated, fits in a biosafety cabinet, and affordable.
It is composed of three main chambers housed in an outer box that fits within a conventionally sized biosafety cabinet. The animal chamber contains a removable housing unit for either four or eight guinea pigs. The aerosol chamber is separate to minimize contamination. The nebulizer chamber is also sealed to reduce risks from leakages. This apparatus is easily decontaminated by immersion in disinfectant.
This system has been tested for safety, ergonomics, efficiency of rodent exposure to bacteria, airflow, access points, seal mechanisms, and size. This system is effective, consistent, safe and cost efficient.
本项目设计并测试了一种经济的仪器，以安全地将豚鼠暴露于生物危害气溶胶中。目标是设计一个易于消毒、可安装在生物安全柜中且价格合理的系统。
它由三个主要腔室组成，装在外箱内，可安装在常规大小的生物安全柜中。动物腔室包含一个可移动的外壳单元，可容纳四只或八只豚鼠。气溶胶腔室是单独的，以尽量减少污染。喷雾器腔室也密封，以降低泄漏风险。该仪器可通过浸泡在消毒剂中轻松消毒。
该系统已针对安全性、人体工程学、细菌暴露于啮齿动物的效率、气流、进入点、密封机制和尺寸进行了测试。该系统有效、一致、安全且具有成本效益。
