Department of Medical Clinic, Division of Endocrinology and Metabolism, UNESP, Botucatu, Brazil.
Eur J Cancer Prev. 2012 Jul;21(4):333-5. doi: 10.1097/CEJ.0b013e32834dbc42.
There are several breast cancer experimental models including cell lines, which are commonly used due to ease of handling and storage. However, the continued propagation of cell lines and distribution among laboratories results in genetic drift and distancing from the in-vivo model. Primary organ culture of breast cancer slices may produce biological responses with high standard deviation for different samples, reflecting the heterogeneity of different tumors. Thus, the organ culture model system offers a new perspective to the results obtained in the cell lines and offers an alternative for studies that seek to individualize treatment for each patient, an increasingly prominent concern in current cancer therapy.
有几种乳腺癌实验模型，包括细胞系，由于易于操作和储存而被广泛使用。然而，细胞系的持续繁殖和在实验室之间的传播会导致遗传漂变，使其与体内模型渐行渐远。乳腺癌切片的原代器官培养可能会产生具有高标准差的生物学反应，这反映了不同肿瘤的异质性。因此，器官培养模型系统为细胞系中获得的结果提供了新的视角，并为那些试图为每个患者进行个体化治疗的研究提供了一种替代方法，这是当前癌症治疗中日益受到关注的问题。
