Hsu M M
Department of Otolaryngology, College of Medicine, National Taiwan University Taipei, Republic of China.
Ear Nose Throat J. 1990 Aug;69(8):543-7.
We studied tumor-host interactions in 47 patients with NPC. The local infiltration of T-lymphocyte subsets was investigated by an immunoperoxidase technique using monoclonal antibodies. Biopsy specimens of patients without cervical metastasis showed more T-lymphocyte (T11) infiltration. The amount of Leu-3a (helper/inducer) and T8 (cytotoxic/suppressor) cell infiltration did not correlate with the age, sex, clinical stage, and peripheral blood T4 and T8 cells of the patients. A higher incidence of Leu-3a cell infiltration was found in patients with high serum IgA antibody titers to EBV VCA. A trend of better prognosis was revealed in those cases with no or slight stromal T8 cell infiltration. A local immune response was found to exist which may prevent the spread of NPC to the cervical nodes, but this needs further study to evaluate the local infiltration of T-lymphocyte subsets as a prognostic indicator.
我们研究了47例鼻咽癌患者的肿瘤-宿主相互作用。采用单克隆抗体免疫过氧化物酶技术研究T淋巴细胞亚群的局部浸润情况。无颈部转移患者的活检标本显示T淋巴细胞（T11）浸润更多。Leu-3a（辅助/诱导）细胞和T8（细胞毒性/抑制）细胞的浸润量与患者的年龄、性别、临床分期及外周血T4和T8细胞均无相关性。血清EBV VCA IgA抗体滴度高的患者中Leu-3a细胞浸润发生率更高。基质T8细胞无浸润或轻度浸润的病例显示出预后较好的趋势。发现存在局部免疫反应，这可能会阻止鼻咽癌向颈部淋巴结扩散，但作为预后指标评估T淋巴细胞亚群的局部浸润情况还需要进一步研究。
