Department of Pediatric Hematology-Oncology, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Leuk Res. 2012 May;36(5):565-9. doi: 10.1016/j.leukres.2011.10.012. Epub 2011 Nov 1.
The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association.
本研究旨在探讨 DNA 修复基因 XPD 和 XRCC1 多态性与发热性中性粒细胞减少症 (FN) 和黏膜炎之间的关联。研究人群包括 29 例伯基特淋巴瘤患儿和 61 例急性淋巴细胞白血病患儿。分析显示，XRCC1194Trp 等位基因对 FN 和黏膜炎的持续时间较长有保护作用。XRCC1Arg399Gln 多态性的患者发生严重黏膜炎的风险也有统计学意义增加。以前没有研究检验过这种关系。需要进一步进行更大队列的研究来阐明这种关联。
