创伤后苔藓纤维发芽与三种小鼠品系的皮质损伤程度有关。
Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains.
机构信息
Department of Physiology, University of Kentucky, Lexington, KY 40536-0298, USA.
出版信息
Epilepsy Res. 2012 Mar;99(1-2):167-70. doi: 10.1016/j.eplepsyres.2011.10.011. Epub 2011 Nov 1.
Abstract
Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.
摘要
采用控制性皮质撞击损伤来研究三个小鼠品系中，局灶性创伤后皮质损伤与齿状回苔藓纤维出芽（MFS）之间的关系。当皮质损伤累及海马时，创伤后 MFS 更为明显，而非局限于皮质的挫伤，且在 CD-1、C57BL/6 和 FVB/N 背景品系中具有相似的定性表现。影响损伤严重程度的撞击参数在重现神经创伤模型中与癫痫相关的变化方面可能是至关重要的。
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