Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.
Opt Lett. 2011 Nov 1;36(21):4176-8. doi: 10.1364/OL.36.004176.
Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice.
使用多光谱光声断层成像技术定量生物标志物可能具有挑战性，因为光子通量随深度而变化，并且组织光学特性在空间上不均匀。本文介绍了一种可以考虑光子通量变化的光谱比方法。该方法在体模和小鼠中进行了数值和实验展示，实现了性能和成像的改善。
