Gannushkina I V, Weinrauder-Semkow G, Mutuskina E A, Gurvich A M, Mossakowski M J
Patol Fiziol Eksp Ter. 1990 May-Jun(3):13-6.
Experiments were conducted on rats with temporary (10-min) clamping of the thoracic vascular bundle and subsequent resuscitation to study the permeability of the blood-brain barrier (BBB) to plasma albumins and globulins and to blood plasma immunoglobulins in different stages of the postresuscitation period. Mild increase of BBB permeability was detected 3 minutes after the beginning of recirculation. Permeability increased markedly in 24 hours and continued growing by the 72nd hour. At a 1-3-hour interval in recirculation the BBB was closed. The obtained results disclose the mechanisms of the development of autoimmune cerebral disorders in an organism that experienced cardiac arrest and resuscitation.
对大鼠进行实验，暂时（10分钟）夹闭胸段血管束并随后进行复苏，以研究复苏后不同阶段血脑屏障（BBB）对血浆白蛋白、球蛋白及血浆免疫球蛋白的通透性。再灌注开始3分钟后检测到血脑屏障通透性轻度增加。24小时时通透性显著增加，并持续增长至72小时。再灌注1 - 3小时期间血脑屏障关闭。所获结果揭示了经历心脏骤停和复苏的机体中自身免疫性脑部疾病的发生机制。
